House Springs is an unincorporated community in Jefferson County, Missouri, United States. It is located just off Route 30 at the intersection with Routes MM and W near Byrnes Mill.A post office has been in operation at House Springs since 1833. The community is named after Adam House, who settled there ca. 1795, and who was killed near a spring by Native Americans.The Valentine Leight General Store and Moder Archeological District are listed on the National Register of Historic Places.